Patients w/ systemic sclerosis; increased possibly fatal incidence of scleroderma renal crisis w/ HTN & decreased urinary output (daily dose ≥15 mg). Routinely check BP & renal function (s-creatinine). Carefully control BP when renal crisis is suspected. Contains aspartame; avoid or limit usage in patients w/ phenylketonuria. Consider referral to an ophthalmologist if patient presents w/ symptoms eg, blurred vision or other visual disturbances. Chronic use in childn may suppress growth & development. Pregnancy.